An extraction from:
Homeopathic Treatment for Bone Regeneration: Experimental Study
Janete Dias Almeida1, Emilia Angela Loschiavo Arisawa2, Ivan Balducci3, Rosilene Fernandes da Rocha1, and Yasmin Rodarte Carvalho1
Original paper Copyright © 2009 The Faculty of Homeopathy Published by Elsevier Ltd.
Extraction of pertinent aims, methods & results shown here, for the purpose of increasing public awareness around homeopathic research
1Department of Bioscience and Oral Diagnosis, São Paulo State University – UNESP, São José dos Campos Dental School, São José dos Campos, São Paulo, Brazil
2Department of Pathology, UNIVAP, Vale do Paraíba University, Health Science Faculty, São José dos Campos, São Paulo, Brazil
3Department of Social Science and Pediatric Dentistry, São Paulo State University – UNESP, São José dos Campos Dental School, São José dos Campos, São Paulo, Brazil
Aim and method
The objective of this research was to study the effect of homeopathic treatment with Plumbum metallicum (Plumbum met.) on mandibular bone repair in rats.
Materials and methods
We analyzed the mandibles of 60 male rats, approximately 3-month-old, randomly divided into three groups of 20 animals each: control, treated with calcitonin, and treated with a homeopathic medicine. A circumscribed bone defect measuring 4 mm in diameter was made in the mandible and covered with a polytetrafluorethylene (PTFE) barrier. The group treated with calcitonin received 2 IU/kg intramuscularly three times a week; the group treated with Plumbum met. 30c received three drops in water every day. The animals were sacrificed after 7, 14, 21 and 28 days. The mandibles were removed and submitted to histologic and histomorphometric analyses.
Data were analyzed statistically by two-way ANOVA and by the Tukey test. The interaction effect (ANOVA, F df(6; 48) = 4.64; p = 0.001 < 0.05) indicated that the relationship between treatments was not the same at each time of sacrifice. Although statistical analysis of the histomorphometric data showed a similar results for the treated and control groups. But histological analysis showed complete filling of the surgical defect throughout its extent was only for the group treated with Plumbum met.
Keywords: Calcitonin; bone regeneration; homeopathy; Plumbum metallicum
Volume 98, Issue 2, April 2009, Pages 92-96